Sample Essay About Happiness

Sample Essay About HappinessThis is a sample essay about happiness. This is not one of those sample essays for the test, this is actually a course of ideas about the topic of the main thesis.There are a lot of ways to write an essay, but I will only tell you one here, which works very well for me. This means that you have to consider what you want to say and then apply the techniques that are meant for writing an essay. Do this until you are able to formulate the best way to express your thoughts.After you have created a good idea about happiness, you should start thinking about the layout of the essay. Make sure that it's informative but also brief and easy to read. You don't need to spend hours or days on it, you just need to keep it simple. Don't be afraid to include illustrations, photographs, tables and maps.When it comes to producing the samples for the sample essays for the test, remember that if the person reading this essay hasn't studied on the topic of happiness, they won' t understand you in the slightest. You need to make sure that you have sufficient knowledge on the topic, or else the test taker will lose their motivation before the tests even begin.If you do write a good idea about happiness, you can have the confidence to present it as the topic of a course. The faculty member can give you an essay sample and even make suggestions about it.With this information in hand, you can then prepare for the actual course material. This essay is very important and you must get through it as fast as possible.For those who want to increase their grades, they should learn how to express themselves better in written form. Writing a sample essay about happiness is a great way to do it.

Scarlet Letter And Scaffold Essays - English-language Films

Scarlet Letter And Scaffold Scaffold "I am as content to die for God's eternal truth on the scaffold as in any other way (Bookshelf)," John Brown, a U.S. abolitionist in 1859, said in a letter to his children on the eve of his execution. The scaffold is a raised wooden framework or platform used for public speaking. It is similar to a stage or a framework. A scaffold is also a platform used in the execution of condemned prisoners, as by hanging or beheading. A scaffold can also be a raised platform, seat or stand used for the purpose of exhibiting persons or actions to the public view (Webster's). A scaffold, similar to a stage, platform or framework, can be permanent. Other types of permanent scaffolds are used in bridges. The basic beam bridge, a simple beam over a span, is strengthened by adding support piers underneath and by reinforcing the structure with elaborate scaffolding called a truss. This method of scaffolding is clearly apparent in most present day bridges, but most travelers do not even realize this fact. The scaffolding includes the huge poles or wires that sit on top of the bridge; this suspension is an extremely advanced scaffold. This method is sometimes also used in suspending a roof. Scaffolds, however, can also be temporary. A scaffold is also a temporary platform, usually suspended on poles from below or suspended from above, on which workers sit or stand during the erection, repairing or decoration of a building. For instance, construction workers stand on scaffolds when building a new structure. Scaffolding allows workers to transport themselves and their materials up and down an unfinished building during construction. Also, a person cleaning the windows of a building must use a scaffold to reach all the windows above ground. Michelangelo used a scaffold to paint the frescoes on the ceiling of the Sistine Chapel in Rome (Groiler's). He worked on a scaffold sixty feet above ground, which covered 10,000 square feet of surface. Another type of temporary scaffold is used in boating and fishing. A flake is a scaffold lowered over the side of a ship to support workers or caulkers when they are either fishing or drying the captured fish (Webster's). The ancient Egyptians can be considered the first people to use temporary scaffolding. The entrance to the Great Pyramid is fifty-five feet above ground level. The entrance was intended for use only once, during King Khufu's funeral (Groiler's). Special scaffolding was erected so the coffin could be placed inside the pyramid. The scaffolding was then dismantled as a safety measure against grave robbers. Scaffold can also be used as a verb. To scaffold could mean to prop up. For instance, new titles may be scaffolded with laws. That is, laws will support the titles. Another, every day, yet connotative, use of the word scaffold would mean to execute. A person who is scaffolded is executed. Scaffold usually denotes a negative, punishing aura when it is used as a verb. As a verb, scaffold is not often used and is a word from early America. Thus, the word can have many different meanings. The scaffold plays an important denotative role in many books, movie and plays. One such book is The Scarlet Letter. The Scarlet Letter by Nathaniel Hawthorne is a story of a young woman, Hester Prynne, living in Puritan dominated Salem, Massachusetts, who commits adultery. The man with whom she engages in the affair is one of the town's Reverends, Mr. Dimmesdale. Hester and Dimmesdale have a baby, Pearl. Hester's husband, Roger Chillingworth, who was missing for two years, returns to find Hester being punished for cheating on him. "Hester Prynne passed through this portion of her ordeal, and came to a sort of scaffold (51)," Hawthorne tells in the opening seen of the novel. In The Scarlet Letter, the scaffold acts as a place for punishment. "This scaffold constituted a portion of a penal machine, which now, for two or three generations past, has been merely historical and traditionary among us, but was held, in the old time, to be as effectual an agent in the promotion of good citizenship, as ever was the guillotine," Hawthorne states in explaining the scaffolds use. The scaffold had wooden steps leading on to it. The steps of the scaffold became the walk of death for many people before they were beheaded. A balcony or open gallery stood over the platform and was attached to the meetinghouse. During Hester's punishment, the ministers and Governor sat in the gallery in order

Dr. Edward Deming Essay

Dr. Edward Deming Essay Free Online Research Papers Dr. Edward Deming is said to be the father of modern quality and a leader in business management. He claimed that an organization must change its organizational behaviors if it had any chance of reaching its highest level of performance. Deming’s work in Japanrebuilding industries after World War II and instructing top executives and engineers in quality managementwas a driving force behind the nations economic rise and their reputation for high-quality products. His advice to Japan made Mr. Deming the leader of a generation of specialists on product durability and reliability who were then sought by American companies trying to catch up to Asian competitors. But his renown in the United States never matched the reputation he achieved in Japan. (Holusha, 1993) However, Deming was relatively unknown in the United States. During wartime in the US, efforts to establish quality-control methods were ignored in favor of a rush to push products out the doors of factories. The prevailing attitude in American culture from the 1950s through the 1970s was that more quality meant higher prices and consumers did not want to pay the prices for high-quality goods which all went against the teachings of Dr. Deming. Deming has published many books and several of his lectures on his philosophy of continual improvement, quality control, and cooperation. Deming is most known for his widely published book, Out of the Crisis in which he writes about the productivity and quality control issues facing businesses and considers the practical responses that management should take. Out of Crises provides a detailed account of Deming’s thinking on how to improve productivity, quality, and competitive advantage and what management’s role needs to be to achieve these increases. Deming claims in Out of the Crisis that managements failure to plan for the future brings about failure in the business. Management must create innovative plans to stay in business, protect investment, ensure future success, and provide more jobs through improved product and service. Deming offered fourteen key principles for management for transforming business effectiveness. The points were first presented in his book Out of the Crisis. (Deming, 1986 p. 23-24) 1. Create constancy of purpose toward improvement of product and service, with the aim to become competitive and stay in business, and to provide jobs. 2. Adopt the new philosophy. We are in a new economic age. Western management must awaken to the challenge, must learn their responsibilities, and take on leadership for change. 3. Cease dependence on inspection to achieve quality. Eliminate the need for inspection on a mass basis by building quality into the product in the first place. 4. End the practice of awarding business on the basis of price tag. Instead, minimize total cost. Move towards a single supplier for any one item, on a long-term relationship of loyalty and trust. 5. Improve constantly and forever the system of production and service, to improve quality and productivity, and thus constantly decrease cost. 6. Institute training on the job. 7. Institute leadership. The aim of supervision should be to help people and machines and gadgets to do a better job. Supervision of management is in need of an overhaul, as well as supervision of production workers. 8. Drive out fear, so that everyone may work effectively for the company. 9. Break down barriers between departments. People in research, design, sales, and production must work as a team, to foresee problems of production and in use that may be encountered with the product or service. 10. Eliminate slogans, exhortations, and targets for the work force asking for zero defects and new levels of productivity. Such exhortations only create adversarial relationships, as the bulk of the causes of low quality and low productivity belong to the system and thus lie beyond the power of the workforce. 11. a. Eliminate work standards (quotas) on the factory floor. Substitute leadership. b. Eliminate management by objective. Eliminate management by numbers, numerical goals. Substitute workmanship. 12. a. Remove barriers that rob the hourly worker of his right to pride of workmanship. The responsibility of supervisors must be changed from sheer numbers to quality. b. Remove barriers that rob people in management and in the engineering of their right to pride of workmanship. This means, inter alia, abolishment of the annual or merit rating and of management by objective. 13. Institute a vigorous program of education and self-improvement. 14. Put everyone in the company to work to accomplish the transformation. The transformation is everyones work. At the core of Deming’s method of quality improvement was his use of statistics to detect flaws in the production process at the company. But, he also developed a broader management philosophy that emphasized problem-solving based on cooperation. He taught managers to encourage their subordinates to take initiative in their jobs and look for ways to improve the process. He encouraged managers to make employees feel comfortable making improvements to the workplace. Deming also introduced his Theory of Profound Knowledge to the world. Profound knowledge theory involves expanded views and an understanding of the seemingly individual yet truly interdependent elements that compose the larger system, the company. Deming believed that every worker has nearly unlimited potential if placed in an environment that adequately supports, educates, and nurtures senses of pride and responsibility; he stated that the majority85 percentof a workers effectiveness is determined by his environment and only minimally by his own skill. (Skymark, 2008) The Deming Cycle or Shewart Cycle describes a simple method to test information before making a major decision. Most will find the four steps in the Deming Cycle familiar, they are, plan, do check and act. Dr. Deming called the cycle the Shewhart Cycle, after Walter A. Shewhart. The Shewhart cycle is still used in various ways, such as running an experiment. Plan (design) the experiment; Do the experiment by performing the steps; Check the results by testing information, and Act on the decisions based on those results. (Wikipedia 2008). The Deming Cycle is not the only of Deming’s theories and ideas that are still valuable today. Many of his philosophies and variations on his theories can be found is some formation in companies around the world. For instance, companies that once had management only perks such as special parking spaces and executive dining rooms have eliminated these perks, to change their entire culture, following Deming’s theory that if workers feel they are part of the team they will work together to improve quality. Citations: Deming, W. E. (1986) Out of the Crisis, MIT Press Holusha, John. (1993, December 21) W. Edwards Deming, Expert on Business Management, Dies at 93, The New York Times http://query.nytimes.com/gst/fullpage.html?res=9F0CE5D81E3BF932A15751C1A965958260sec=spon=pagewanted=all Skymark. (2008). Retrieved December 9, 2008, from: skymark.com/resources/leaders/deming.asp Wikipedia. (2008). Retrieved December 9, 2008 from: http://en.wikipedia.org/wiki/Edward_Deming#Quotations_and_concepts Research Papers on Dr. Edward Deming EssayInternational PaperFalse AdvertisingProject Management 101Definition of Export QuotasDeveloping Branding StrategiesYear Round SchoolingGap Analysis: Lester ElectronicsA Marketing Analysis of the Fast-Food RestaurantGovernment Funding EssayEthics in Business Essay

Governing global business Article Example | Topics and Well Written Essays - 2000 words

Governing global business - Article Example Galbraith asserts that the classical economy theories were only true in the past millenniums and argues that those were the days when the society lived in poverty. The current civil society has advanced from the poor lifestyle to affluence and as a result, a completely new economic theory has developed. The businesses have developed and they are turning from local to global marketing, most of the business ventures are forced to put in place a frame work of operation that embraces accountability and global recognition otherwise they would greatly degrade their technique. There are many small organisations that have come together to fight for fare trade that would ensure corporate responsibility. Galbraith argues that as the society becomes more affluent, the trends in economic theory should also change towards generating consumer demand artificially. Business ventures have to advertise so as to create that need in their customers and produce commercial goods and services; this has brought about neglect to the public sector (Galbraith & Galbraith 2007). Galbraith asserts that with the wealth around, many people for example Americans may tend to purchase luxurious items while their backyard was polluted and their children attended poorly managed schools. He also argues that the presence of the market alone would under supply or totally fails to provide for a lot of consumer goods to the general public while private commodities would be characteristically over provided due to the advertising process which effectively creates an artificial demand above the individual's fundamental requirements. Galbraith advocates for regulated consumption of certain products by imposing greater consumption taxes with grounds that would be a better form of taxation compared to labour and land taxes. Legislating the corporate responsibility to meet the expectations of multi-national democracy. These regulations need the intervention of bodies like European Union, national governments and other non-governmental organisations. The increasing influence of TNCs on the global market is posing a threat to some governments and small businesses and hence it should be tamed to attain global responsibility (Galbraith & Galbraith 2007). TNC Power and Globalization Most of the trans-national corporations have resulted in abuse of human rights (in terms of salaries and goods) since they have attained sudden domination and unexplained powers over the political and economic scene. The need for decentralized power and the complicated relationship of the regulation and influence that is typical for today's economy pose a challenge to the accountability and responsibility of advertisements and the safeguarding of the human rights (Galbraith & Galbraith 2007). Globalization is the major motivation factor to the emergence of the trans-national corporations and multinational business ventures as the major players in the international stage. Since these corporations have high economic capabilities, they tend to override their ability and operations to influence or manipulate political and ec

UK Immigration Policies Exclude Asylum Seekers Essay

UK Immigration Policies Exclude Asylum Seekers - Essay Example Most of the UK local councils and Government organizations define an asylum seeker as â€Å"someone who enters its territory, seeks refugee status and awaits a decision by its Government on his / her application† (London Borough of Hammersmith and Fulham, n. d.). This means that anyone who enters the UK territory for some reasons of persecution from another country and applies for a refugee status remains officially an asylum seeker as long as the application remains pending. Asylum seekers whose applications are accepted would become refugees. But, part 6 of the 1999 Immigration and Asylum Act of the UK explains that the term ‘asylum seekers’ also includes those â€Å"who have made no claim for protection under the 1951 Convention relating to the Status of Refugees and its Optional Protocol of 1967†. The term also includes those people who have children under the age of 18 but failed in their asylum claim (Harvey, 2002: 189). There are researchers who correctly think that a clear-cut definition is lacking for these terms resulting in confusion on a relationship between asylum and international protection (Kourala, 1997: 274). Several countries have their own independent immigration laws and policies to deal with the asylum seekers and the UK has also been pursuing its own immigration policy. The policy has surely an objective to achieve. A close examination of its policies and laws reveal that the policies are guided by the objective of discouraging the increasing number of immigrants entering the country. Available literature on immigration and asylum seekers suggests that majority of the UK people, like the other Europeans, are ready to accept the increasing inflow of immigrants on the condition that immigrants learn all types of skilled work, that they do not seek full welfare benefits and that they accept and adopt the host culture (Liddle and Diamond, 2006: 26).

Role of Genes and Environment in the Aetiology of Schizophre

Role of Genes and Environment in the Aetiology of Schizophre INTRODUCTION Schizophrenia (schiz = splitting; phrene = mind) is generally characterized as the fragmentation of psychic functions (Bleuler, 1950) of which the absolute causes are unknown. It is defined and diagnosed based on Schneider (1959)’s ‘first rank symptoms’ which can be further categorized into positive (e.g. hallucination, delusion, etc.) and negative (e.g. avolition, catatonia, etc.), depending on the described and observed experiences of patients (Andreasen Olsen, 1982). This essay aims to review a wide range of scientific literature and research which attempted to study the influence of various genetic and environmental factors in the aetiology of schizophrenia based on the general assumption that this mental illness is a multifactorial disease and can be viewed as an outcome of gene-environmental interaction (Van Os, Rutten, Poulton, 2008). A case study on the effect of Cannabis use on schizophrenia (Caspi et al., 2005) is analysed in order to justify the signi ficance of gene-environment interaction. GENETIC FACTORS The study of genes and how they contribute to the aetiology of schizophrenia have always been the topics of interest for neurobiologist. Multiple twins studies have shown that identical twins of 100% shared genes carry almost 40 times higher risk than completely unrelated people in developing such mental disorder if one of them was schizophrenic (Kallman, 1946; Cardno et al., 1999). In fact, schizophrenia is a polygenic illness as no single significant schizophrenia gene has been identified and numerous candidate genes such as Dystrobrevin-binding protein 1 (dysbindin), neuregulin 1 (NRG1), Catechol-O-methyltransferase protein (COMT), and Disrupted-in Schizophrenia 1 (DISC1) are the aetiological factors (Ross et al., 2006). This essay intends to discuss the role of COMT with respect to the ‘dopamine hypothesis’ and dysbindin corresponding to the ‘glutamate hypothesis’. Two neurochemical models have evolved to become important theories accounting for the aetiology of schizophrenia. The dominant one is the ‘dopamine hypothesis’ which pinpointed the association of hyperfunction of dopamine system, critically at D2 receptors, with schizophrenia (Carlsson, 1988) but it is being challenged (Egan et al., 2001) and will be discussed in next section. Another recent model will be the ‘glutamate hypofunction hypothesis’ which suggested that N-methyl-D-aspartate (NMDA) receptors dysfunction and deficiency in glutamate production can lead to negative symptoms of schizophrenia (Olney, 1999; Coyle, 2006). ‘Dopamine hypothesis’ challenged: Introduction of inverted â€Å"U† model for COMT as the regulator of dopaminergic transmission COMT gene, being located at chromosome 22q11.2, is involved in the synthesis of dopamine metabolic enzyme and it regulates the dopaminergic transmission across synapses in the prefrontal cortex (Craddock et al., 2006; Tunbridge et al., 2006). Microdeletion of this chromosomal region resulted in Velo-cardio-facial syndrome (VCFS) and approximately one third of the patients suffering from VCFS were diagnosed to be with schizophrenia (Murphy et al., 1999), depictingthe significance of COMT in aetiology of schizophrenia via regulation of the release of dopamine transmitters in PFC. Two alleles, valine (Val) and methione (Met), found on COMT are involved in the functional polymorphism which alters the activity of dopamine metabolic enzyme. The relatively lower stability of the Met allele resulted in the lower enzyme activity, which in turn reduced dopamine breakdown and increased the concentration of dopaminergic transmission in the synapses. Consequently, individuals with Met-Met genotype were expected to be more susceptible to schizophrenia (Ross et al., 2006). In contrast, research has challenged the ‘dopamine hypothesis’ by demonstrating that both the patients with schizophrenia and individuals that inherited two copies of Val alleles (with decreased prefrontal dopamine level) exhibited the lowest PFC efficiency (Egan et al., 2001). This leads to the introduction of an inverted â€Å"U† model (see Figure 1) which illustrates the relationship between COMT genotype, PFC dopamine levels and prefrontal activity (Cools DEsposito, 2011). Glutamate hypothesis: Dysbindin as the regulator of glutamatergic transmission Dysbindin gene, being located at chromosome 6p22.3, was identified to have strong association with schizophrenia (Straub et al., 2002). There is a wide colocalisation of this gene with dystrobreyin in both presynaptic and postsynaptic regions of brain such as hippocampus (Benson et al., 2001). The level of dysbindin expression in the hippocampus and prefrontal cortex (PFC) of schizophrenia patients is consistently found to be significantly reduced (Talbot et al. 2004, Bray et al., 2005; Weickert et al, 2008). As a result of knockdown of endogenous dysbindin protein in culture by siRNA, a small interfering RNA, glutamatergic neurotransmission can be reduced. (Numakawa et al., 2004; Talbot et al., 2004). Besides, the reduced expression also significantly suppresses the synaptic transmission of glutamate in Drosophila’s brain (Shao et al., 2011) and reduces the excitation of NMDA as well as the expression of NR1 mRNA in the PFC of mice (Karlsgodt et al., 2011). These findings wel l supported the ‘glutamate hypothesis’ of schizophrenia, which proposed this mental disorder as an outcome of dysfunction of NMDA receptors and glutamatergic transmission. Limitations Although microdeletion of chromosome 22q11.2 increases vulnerability to schizophrenia, it is important to note that there might be other genes on the same location that can account for such illness as COMT is not the only gene in this location. Moreover, in contrast to the glutamate hypothesis’, reduced dysbindin expression in the hippocampus of mice increases NMDA-mediated current and long-term potentiation and increase glutamatergic transmission (Tang et al., 2009). This suggests that ‘glutamate hypothesis’ might not be applicable to the role of dysbindin in all brain areas. ENVIRONMENTAL FACTORS Studies using the approach of Magnetic Resonance Imaging (MRI) have consistently discovered significant brain abnormalities in schizophrenics such as reduced frontal lobes and cerebral cortex (Andreasen et al., 1986) which affected cognitive abilities. Reduced frontal cortex was later shown to have no correlation with familial influence but with environmental factors (Owen et al., 2012). Although Touloupoulou et al. (2010)’s study has demonstrated that genetic factors can explain the correlation between cognition and schizophrenia, the research also suggested that environmental factors can account for the weak link between them. This essay will then discuss the influence of prenatal and postnatal risk factors as well as childhood trauma in the aetiology of schizophrenia. Prenatal and postnatal risk factors in aetiology of brain abnormalities A meta-analysis has demonstrated the strong correlation between schizophrenia and prenatal or obstetric complications such as below standard birth weight, premature birth and perinatal hypoxic brain damage (Cannon, Jones Murray, 2002). During prenatal stage, deficiency in micronutrients such as folate, iron and vitamin D can interrupt physical development of fetus and result in low birth weight (Brown Susser, 2008). Maternal exposure to infectious pathogens such as herpes simplex virus type-2, rubella, polio etc. can also impact neurodevelopment in fetus and raise the vulnerability of offspring towards schizophrenia. Furthermore, hynoxia (deficiency in oxygen level) during perinatal stage significantly influences the development of gray matter which in turn induces schizophrenia (Opler et al., 2013). Childhood trauma and experiences in aetiology of abnormal functional and structural brain development Positive symptoms of schizophrenia such as hallucination is of strong association with undesirable childhood experiences such as abuse and neglect. Childhood trauma acts as a stressor which adversely alters the dopamine production system in hippocampus. Accordingly, the accumulated effect of abuse can trigger dysregulation of dopaminergic transmission as well as the onset of schizophrenia (Read, Os, Morrison Ross, 2005). The abnormal dopamine level (either too high or too low) is linked with the aetiology of schizophrenia, corresponding to the inverted ‘U’ model (Cools DEsposito, 2011). In addition, childhood abuse can lead to traumatic brain injury (TBI) which results in neurodegeneration and significant volume loss in various brain regions and eventually leads to the onset of psychosis (Keightley, 2014). 1316 GENE-ENVIRONMENT INTERACTION Case Study: COMT genotypes moderates the effect of adolescent cannabis-use on risk of schizophrenia in adulthood Strong evidences have signified the use of cannabis in adolescence as the modest risk factors for schizophrenia. Early use of cannabis is capable of increasing the risk of brain abnormalities and schizophrenia because the brains of adolescents are still under development and brain maturation is extremely susceptible to the deleterious effect cannabis use (Ehrenreich et al 1999; Pistis et al 2004; Pope et al 2003; Schneider and Koch 2003). Nonetheless, this environmental factor alone cannot be regarded as an aetiology of such mental disorder because a vast majority of the cannabis adolescent users do not exhibit schizophrenic disorders in adulthood (Caspi et al., 2005). Hence, the vulnerability of individuals towards adolescent-onset use of cannabis suggests a gene-environment interaction. In fact, COMT gene, as discussed above, is involved in regulating such trait. Individuals who have two copies of Val alleles carry the highest risk of schizophrenia at age 26 if cannabis abuse was f ound in their early stages, followed by Met-Val genotypes and adolescents who inherited Met-Met COMT genotype are least vulnerable to the abuse use of cannabis (Caspi et al., 2005). Thus, this clearly demonstrates the moderation effect of COMT on cannabis use and the gene-environment interaction. CONCLUSION In conclusion, understanding the role of various genes such as COMT and dysbindin in regulating the neurotransmission can help developing adequate medications which effectively tackle the mental illness. Identifying the influence of prenatal and obstetric complications as well as childhood experiences in aetiology of schizophrenia can also effectively prevent the onset of schizophrenia. Last but not least, studying the gene-environment interaction in the case of cannabis use reveals the multifactorial properties and intricate aetiology of schizophrenia. Hence, future research is encouraged to work on such interaction in order to pinpoint the main causes of such mental disorder. REFERENCES Andreasen, N. C., Olsen, S. (1982). Negative v positive schizophrenia: definition and validation.Archives of General Psychiatry,39(7), 789. Bleuler, E. (1950). Dementia praecox or the group of schizophrenias. Oxford/England: International Universities Press. 548. Carlsson, A. (1988). The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology. Cardno AG, Marshall EJ, Coid B, Macdonald AM, Ribchester TR, Davies NJ, et al. (1999). Heritability estimates for psychotic disorders.Arch Gen Psychiatry,56 (162), 8. Kallmann, F. J. (1946). The genetic theory of schizophrenia: an analysis of 691 schizophrenic twin index families.American Journal of Psychiatry,103(3), 309-322. Kety, S. S. R. D., Rosenthal, D., Wender, P. H., Schulsinger, F., Jacobsen, B. (1974). Mental illness in the biological and adoptive families of adopted individuals who have become schizophrenic: A preliminary report based upon interviews with the relatives.Journal of Psychiatric Research,10(2), 154. Ingraham, L. J., Wender, P. H., Kety, S. S. (1991). Characterization of genetically transmitted schizophrenia in Danish adoptees.Schizophrenia Research,4(3), 279-280. Ross, C. A., Margolis, R. L., Reading, S. A., Pletnikov, M., Coyle, J. T. (2006). Neurobiology of schizophrenia.Neuron,52(1), 139-153. Straub, R. E., Jiang, Y., MacLean, C. J., Ma, Y., Webb, B. T., Myakishev, M. V., Kendler, K. S. (2002). Genetic variation in the 6p22. 3 Gene DTNBP1 the human ortholog of the mouse dysbindin gene is associated with schizophrenia.The American Journal of Human Genetics, 71(2), 337-348. Shao, L., Shuai, Y., Wang, J., Feng, S., Lu, B., Li, Z., Zhong, Y. (2011). Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila.Proceedings of the National Academy of Sciences,108(46), 18831-18836. Olney, J. W., Newcomer, J. W., Farber, N. B. (1999). NMDA receptor hypofunction model of schizophrenia.Journal of psychiatric research,33(6), 523-533. Coyle, J. T. (2006). Glutamate and schizophrenia: beyond the dopamine hypothesis.Cellular and molecular neurobiology,26(4-6), 363-382. Talbot, K., Eidem, W. L., Tinsley, C. L., Benson, M. A., Thompson, E. W., Smith, R. J., Arnold, S. E. (2004). Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. The Journal of clinical investigation, 113(9), 1353-1363. Weickert, C. S., Rothmond, D. A., Hyde, T. M., Kleinman, J. E., Straub, R. E. (2008). Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophrenia research, 98(1), 105-110. Karlsgodt, K. H., Robleto, K., Trantham-Davidson, H., Jairl, C., Cannon, T. D., Lavin, A., Jentsch, J. D. (2011). Reduced dysbindin expression mediates N-Methyl-D-Aspartate receptor hypofunction and impaired working memory performance. Biological psychiatry, 69(1), 28-34. Tang, T. T. T., Yang, F., Chen, B. S., Lu, Y., Ji, Y., Roche, K. W., Lu, B. (2009). Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression. Proceedings of the National Academy of Sciences, 106(50), 21395-21400. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Weinberger, D. R. (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.Proceedings of the National Academy of Sciences,98(12), 6917-6922. Cools, R., DEsposito, M. (2011). Inverted-U–Shaped Dopamine actions on human working memory and cognitive control.Biological psychiatry,69(12), e113-e125. Opler, M., Charap, J., Greig, A., Stein, V., Polito, S., Malaspina, D. (2013). Environmental risk factors and schizophrenia.International Journal of Mental Health,42(1), 23-32. Gottesman, I. I., Bertelsen, A. (1989). Confirming unexpressed genotypes for schizophrenia: risks in the offspring of Fischers Danish identical and fraternal discordant twins.Archives of General Psychiatry,46(10), 867-872. Toulopoulou, T., Goldberg, T. E., Mesa, I. R., Picchioni, M., Rijsdijk, F., Stahl, D., Murray, R. M. (2010). Impaired intellect and memory: a missing link between genetic risk and schizophrenia?.Archives of general psychiatry,67(9), 905-913. Manoach, D. S. (2003). Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings.Schizophrenia research,60(2), 285-298. Owens, S. F., Picchioni, M. M., Ettinger, U., McDonald, C., Walshe, M., Schmechtig, A., Toulopoulou, T. (2012). Prefrontal deviations in function but not volume are putative endophenotypes for schizophrenia.Brain, 138. Cannon, M., Jones, P. B., Murray, R. M. (2002). Obstetric complications and schizophrenia: historical and meta-analytic review.American Journal of Psychiatry,159(7), 1080-1092. Brown, A.S., Susser, E.S. (2008). Prenatal nutritional deficiency and risk of adult schizophrenia. Schizophrenia Bulletin, 34, 1054–1063 Read, J., Os, J. V., Morrison, A. P., Ross, C. A. (2005). Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications.Acta Psychiatrica Scandinavica,112(5), 330-350. Van Os, J., Rutten, B. P., Poulton, R. (2008). Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophrenia bulletin,34(6), 1066-1082. Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Craig, I. W. (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction.Biological psychiatry,57(10), 1117-1127. Keightley, M. L., Sinopoli, K. J., Davis, K. D., Mikulis, D. J., Wennberg, R., Tartaglia, M. C., Tator, C. H. (2014). Is there evidence for neurodegenerative change following traumatic brain injury in children and youth? A scoping review.Frontiers in human neuroscience,8. Schneider, K. (1959) Klinische Psychopathologie. New York/Stuttgart : Thieme Verlag.

NeoMed Tech

Subject line: Describe what went right and what went wrong with this venture. Add in how you would fix the Identified problems, If this was your company. Needed Technologies developed a diagnostic device used for cardiac testing, and is headquartered in Ohio. They developed a CAD screen system to detect coronary artery disease. The company was founded in 2000 and is based in Cleveland, Ohio.Needed Technologies was faced with a lot of difficult decisions at the beginning when it came to where their product would best fit and be most successful. They ad developed a technology that could fit Into many markets, but needed to choose a product path and market. Their continued challenges occurred due to the changes In the market direction of venture capital opportunities and the funding available, all due to changes in the economy at that time.Due to the lack of funding, and a continued decline in Venture Capital funding along with a downturn in the economy; I believe had the economic situa tion been different at the time when they needed venture capital funding, the would've faced less challenges. The management team and Board of Directors were selected carefully and all had the experience and the background needed for success In the product market space. Needed Technologies had a strong business plan, and had conducted extensive research in initial planning stages.I believe based on the reading materials in this chapter; they did all the right things in the planning and early development stages. Although Needed Technologies had to contend with big name competitors and major players in the diagnostic and imaging market such as GE Medical and Philips, also located in the Ohio region; their strategy to be headquartered in Ohio was a sound decision. However, they should've investigated further in the opportunity to obtain venture capital funding outside of the Ohio region.Perhaps they could've spent more time studying competitive business cases of companies Like competit or, Heartaches, who specializes In the BEST test. The Heartaches product, although more costly, had seen success and was widely accepted in the Medical field. Despite the added cost of the Heartaches BEST test, they were seeing success in the market. One strategy change I would've considered early on was not applying all resources of their technology into one area.Needed Technologies should've considered applying their initial product development to the technology of screening for drugs, drug delivery applications or detecting cancer. These areas would've possibly allowed for a quick to market product, without the additional approvals, quality standards applied in the medical equipment space, and FDA approvals needed. Bringing a simpler product to market first could've brought in revenue to fund the long-term reduce focus off CAD screen system.The profits from a drug screening or drug delivery product could've assisted in funding their long-term product focus, they missed an opportu nity to develop a quick revenue steam. Defense space, for detection of nuclear weapons, or dirty bombs. With the shift later in Venture Capital funding opportunities, they could've experienced success in this area as well. Bottom-line, they put all their eggs in one basket; they failed to have a backup product to develop a quick revenue stream to further fund their long-term goal.However, without a crystal ball that was a difficult decision. There were clear signs of shifts in investment opportunities, the shift indicted investments being shifted towards Homeland Security, military applications, and protection from various biological and chemical threats. Needed Technologies should shift some of their resources to developing a product to fit into that area, thus allowing them the opportunity to obtain additional venture capital funding, and perhaps developing a profitable product in the Homeland Security space.The revenue stream from this reduce would allow them later to proceed wit h their CAD screen system. There was another area of investment that should've been further investigated, â€Å"Angel Investors†, most of who are Entrepreneurs themselves currently, or at some point in their career. Inviting one of the Angel investors a seat on the board, as well as leveraging the experience they have gained from starting their own company, dealing with the challenges of starting a business, and investigating further Venture capital funding areas.Needed Technologies should've reached out farther than Just the Ohio-based Venture Capital firms, this would've allowed them a broader audience of investors and opportunity. I don't believe holding off for perfection is necessarily wrong, especially when dealing with, and factoring in the value of human life. The Needed Technologies board of directors and upper level management all appeared to encompass strong ethics and while that might be a weakness to others, ethics are important and should never be compromised. T oo many companies take the short cut to success and people get hurt.